:root{color-scheme:light;--teal-50: #f0fdfa;--teal-100: #ccfbf1;--teal-200: #99f6e4;--teal-600: #0d9488;--teal-700: #0f766e;--teal-800: #115e59;--sky-50: #f0f9ff;--sky-100: #e0f2fe;--orange-50: #fff7ed;--orange-500: #f97316;--orange-700: #c2410c;--orange-800: #9a3412;--amber-50: #fffbeb;--amber-800: #92400e;--ink-900: #0f172a;--ink-700: #334155;--ink-600: #475569;--ink-500: #64748b;--ink-300: #cbd5e1;--ink-200: #e2e8f0;--ink-100: #f1f5f9;--ink-50: #f8fafc;--danger-50: #fef2f2;--danger-700: #b91c1c;--success-700: #047857;--font-ui: "Inter", "PingFang TC", "Noto Sans TC", "Microsoft JhengHei", system-ui, sans-serif;--font-code: "SFMono-Regular", Menlo, Consolas, "PingFang TC", monospace;--radius-card: 16px;--radius-control: 10px;--shadow-card: 0 1px 2px rgba(15, 23, 42, .04), 0 8px 24px -12px rgba(15, 23, 42, .12);--shadow-raised: 0 12px 32px -12px rgba(15, 118, 110, .28)}*,*:before,*:after{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:16px}body{margin:0;font-family:var(--font-ui);font-size:16px;line-height:1.65;color:var(--ink-700);background:var(--ink-50);-webkit-font-smoothing:antialiased}h1,h2,h3,h4,h5,p,ul,ol,dl,dd{margin-top:0}img{max-width:100%;height:auto}a{color:var(--teal-700)}:focus-visible{outline:3px solid var(--orange-500);outline-offset:2px}.shell{width:100%;max-width:1120px;margin:0 auto;padding:0 24px}.visually-hidden{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}.skip-link{position:absolute;left:16px;top:-60px;z-index:100;padding:10px 16px;border-radius:var(--radius-control);background:var(--ink-900);color:#fff}.skip-link:focus{top:12px}.app-header{background:#fff;border-bottom:1px solid var(--ink-200)}.app-header-inner{display:flex;align-items:center;justify-content:space-between;gap:16px;min-height:72px}.brand{display:flex;align-items:center;gap:12px}.brand-mark{display:grid;place-items:center;flex:none;width:42px;height:42px;border-radius:12px;background:linear-gradient(135deg,var(--teal-600),var(--teal-800));color:#fff;box-shadow:var(--shadow-raised)}.brand-mark svg{width:22px;height:22px}.brand-title{margin:0;font-size:1.2rem;font-weight:800;line-height:1.2;color:var(--ink-900)}.brand-subtitle{display:block;font-size:.82rem;color:var(--ink-500)}.maker{display:flex;flex-direction:column;align-items:flex-end;line-height:1.3;text-decoration:none}.maker-label{font-size:.75rem;color:var(--ink-500)}.maker-name{font-size:.92rem;font-weight:700;color:var(--teal-700)}.maker:hover .maker-name{color:var(--orange-700)}.main{padding-top:32px;padding-bottom:72px}.hero{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,.9fr);align-items:center;gap:32px;margin-bottom:24px;padding:36px 40px;border:1px solid var(--ink-200);border-radius:24px;background:radial-gradient(circle at 85% 20%,var(--sky-100),transparent 55%),radial-gradient(circle at 70% 90%,var(--teal-50),transparent 50%),#fff;box-shadow:var(--shadow-card)}.eyebrow{margin:0 0 10px;font-size:.8rem;font-weight:700;letter-spacing:.12em;color:var(--orange-700)}.hero h2{margin-bottom:14px;font-size:clamp(1.6rem,3vw,2.35rem);font-weight:800;line-height:1.28;color:var(--ink-900)}.lead{margin:0;font-size:1.02rem;color:var(--ink-600)}.hero-art{display:block;width:100%;mix-blend-mode:multiply}.input-section,.articles-section,.terms-section,.queries-section,.blog-section,.loading-section,.warnings-section,.how-it-works{margin-bottom:24px;padding:28px;border:1px solid var(--ink-200);border-radius:var(--radius-card);background:#fff;box-shadow:var(--shadow-card)}.articles-section h2,.terms-section h2,.queries-section h2,.blog-section h2,.how-it-works h2,.warnings-section h3{margin-bottom:16px;font-size:1.3rem;font-weight:800;color:var(--ink-900)}.section-header{display:flex;flex-wrap:wrap;align-items:center;justify-content:space-between;gap:12px;margin-bottom:16px}.section-header h2{margin:0}.section-description,.hint{color:var(--ink-600);font-size:.93rem}.input-grid{display:grid;grid-template-columns:minmax(0,1.2fr) minmax(0,1fr);gap:24px;margin-bottom:16px}.input-panel{display:flex;flex-direction:column}.input-panel.validation-set{padding:16px;border:1px dashed var(--ink-300);border-radius:12px;background:var(--ink-50)}.input-label{display:flex;align-items:center;gap:8px;font-weight:700;color:var(--ink-900)}.required,.optional{padding:2px 8px;border-radius:999px;font-size:.72rem;font-weight:700}.required{background:var(--orange-50);color:var(--orange-800)}.optional{background:var(--teal-50);color:var(--teal-800)}.input-help{margin:4px 0 10px;font-size:.86rem;color:var(--ink-600)}textarea,input[type=text],input[type=password],select{width:100%;border:1px solid var(--ink-300);border-radius:var(--radius-control);background:#fff;color:var(--ink-900);font:inherit;font-size:.95rem;transition:border-color .15s,box-shadow .15s}textarea{flex:1;min-height:132px;padding:12px;font-family:var(--font-code);resize:vertical}input[type=text],input[type=password],select{min-height:44px;padding:10px 12px}textarea:focus,input:focus,select:focus{outline:none;border-color:var(--teal-600);box-shadow:0 0 0 3px var(--teal-100)}textarea::placeholder,input::placeholder{color:var(--ink-500)}.pmid-stats{display:flex;flex-wrap:wrap;align-items:center;gap:6px 12px;margin-top:8px;font-size:.86rem}.pmid-count{padding:2px 10px;border-radius:999px;font-weight:700}.pmid-count.good{background:var(--teal-50);color:var(--teal-800)}.pmid-count.warning{background:var(--amber-50);color:var(--amber-800)}.pmid-count.error,.error-text{color:var(--danger-700)}.pmid-count.error{background:var(--danger-50)}.warning-text,.duplicate-warning{color:var(--amber-800)}.btn{display:inline-flex;align-items:center;justify-content:center;gap:8px;min-height:44px;padding:10px 20px;border:1px solid transparent;border-radius:var(--radius-control);font:inherit;font-weight:700;cursor:pointer;transition:background-color .15s,border-color .15s,color .15s}.btn:disabled{opacity:.55;cursor:not-allowed}.btn-primary{background:var(--orange-700);color:#fff}.btn-primary:hover:not(:disabled){background:var(--orange-800)}.btn-secondary,.btn-export,.btn-cancel{background:#fff;border-color:var(--ink-300);color:var(--ink-700)}.btn-secondary:hover:not(:disabled),.btn-export:hover:not(:disabled),.btn-cancel:hover:not(:disabled){border-color:var(--teal-600);color:var(--teal-800)}.btn-export{min-height:38px;padding:6px 14px;font-size:.86rem}.btn-blog{background:var(--teal-700);color:#fff}.btn-blog:hover:not(:disabled){background:var(--teal-800)}.btn-link{padding:0;border:0;background:none;color:var(--teal-700);font:inherit;font-weight:600;text-decoration:underline;cursor:pointer}.copied{background:var(--teal-700)!important;color:#fff!important}.button-row,.export-buttons,.blog-buttons,.blog-actions{display:flex;flex-wrap:wrap;gap:10px}.button-row{margin-top:20px}.advanced-toggle{display:inline-flex;align-items:center;gap:6px;margin-top:4px;padding:6px 0;border:0;background:none;color:var(--teal-700);font:inherit;font-weight:700;cursor:pointer}.advanced-settings{margin-top:12px;padding:20px;border:1px solid var(--ink-200);border-radius:12px;background:var(--ink-50)}.advanced-settings h3{margin-bottom:6px;font-size:1rem;color:var(--ink-900)}.production-note{display:block;margin-top:4px;color:var(--amber-800)}.settings-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(200px,1fr));gap:14px;margin-top:14px}.setting-row label{display:block;margin-bottom:6px;font-size:.85rem;font-weight:600;color:var(--ink-700)}.test-llm-row{display:flex;flex-wrap:wrap;align-items:center;gap:12px;margin-top:16px}.step-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:20px}.step-card{padding:20px;border:1px solid var(--ink-200);border-radius:14px;background:var(--ink-50)}.step-card img{display:block;width:160px;height:130px;margin:0 auto 12px;object-fit:contain;mix-blend-mode:multiply}.step-card h3{margin-bottom:6px;font-size:1.02rem;color:var(--ink-900)}.step-card p{margin:0;font-size:.9rem;color:var(--ink-600)}.how-note{margin:16px 0 0;padding:12px 14px;border-left:3px solid var(--orange-500);border-radius:0 var(--radius-control) var(--radius-control) 0;background:var(--orange-50);font-size:.88rem}.loading-section{text-align:center}.loading-spinner{width:40px;height:40px;margin:0 auto 12px;border:4px solid var(--teal-100);border-top-color:var(--teal-700);border-radius:50%;animation:spin .9s linear infinite}@keyframes spin{to{transform:rotate(360deg)}}.progress-container{margin:12px 0}.progress-bar{height:8px;border-radius:999px;background:var(--ink-100);overflow:hidden}.progress-fill{height:100%;border-radius:999px;background:linear-gradient(90deg,var(--teal-600),var(--orange-500));transition:width .4s ease}.progress-text{margin-top:6px;font-size:.85rem;color:var(--ink-500)}.loading-steps{display:grid;gap:6px;max-width:420px;margin:12px auto;text-align:left}.loading-step{display:flex;gap:10px;color:var(--ink-500);font-size:.9rem}.loading-step.active{color:var(--teal-800);font-weight:700}.loading-step.completed{color:var(--ink-700)}.error-message{display:flex;gap:12px;margin-bottom:24px;padding:16px 20px;border:1px solid #fecaca;border-radius:12px;background:var(--danger-50);color:var(--danger-700)}.error-hint{margin:4px 0 0;font-size:.88rem;color:var(--ink-600)}.warnings-section{border-color:#fde68a;background:var(--amber-50)}.warnings-section h3{color:var(--amber-800)}.warnings-list{margin:0;padding-left:1.2em;color:var(--amber-800);font-size:.92rem}.warnings-list li{margin-bottom:4px}.result-nav{position:sticky;top:0;z-index:20;display:flex;flex-wrap:wrap;gap:8px;margin-bottom:16px;padding:10px 12px;border:1px solid var(--ink-200);border-radius:14px;background:#fffffff2;-webkit-backdrop-filter:blur(8px);backdrop-filter:blur(8px)}.result-nav a{display:inline-flex;align-items:center;gap:8px;padding:6px 12px;border-radius:999px;background:var(--ink-100);color:var(--ink-700);font-size:.88rem;font-weight:600;text-decoration:none}.result-nav a:hover{background:var(--teal-50);color:var(--teal-800)}.result-nav span{display:grid;place-items:center;width:20px;height:20px;border-radius:50%;background:var(--teal-700);color:#fff;font-size:.75rem}#section-articles,#section-terms,#section-queries,#section-blog{scroll-margin-top:72px}.meta-info{margin-bottom:16px;font-size:.85rem;color:var(--ink-500)}.method-note{margin:4px 0 0;padding:10px 14px;border-left:3px solid var(--orange-500);border-radius:0 var(--radius-control) var(--radius-control) 0;background:var(--orange-50);color:var(--ink-700)}.article-card{margin-bottom:12px;padding:16px 18px;border:1px solid var(--ink-200);border-radius:12px}.article-pmid-link{display:inline-block;margin-bottom:6px;padding:2px 10px;border-radius:999px;background:var(--teal-50);font-size:.82rem;font-weight:700;text-decoration:none}.article-title{margin-bottom:4px;font-weight:700;color:var(--ink-900)}.article-meta{margin-bottom:8px;font-size:.85rem;color:var(--ink-500)}.article-mesh{display:flex;flex-wrap:wrap;align-items:center;gap:6px;font-size:.8rem}.mesh-label{color:var(--ink-500)}.mesh-tag,.mesh-more,.source-badge{padding:2px 8px;border-radius:6px;background:var(--sky-50);color:var(--ink-700);font-size:.78rem}.source-badge.mesh-major{background:var(--teal-50);color:var(--teal-800);font-weight:700}.terms-filter{display:flex;flex-wrap:wrap;gap:8px;margin-bottom:14px}.filter-btn{min-height:36px;padding:6px 14px;border:1px solid var(--ink-300);border-radius:999px;background:#fff;color:var(--ink-700);font:inherit;font-size:.86rem;font-weight:600;cursor:pointer}.filter-btn.active{border-color:var(--teal-700);background:var(--teal-700);color:#fff}.table-container{overflow-x:auto}.terms-table{width:100%;border-collapse:collapse;font-size:.9rem}.terms-table th{padding:10px 12px;border-bottom:2px solid var(--ink-200);color:var(--ink-600);font-size:.8rem;text-align:left}.terms-table td{padding:10px 12px;border-bottom:1px solid var(--ink-100)}.role-badge{display:inline-grid;place-items:center;min-width:28px;padding:2px 8px;border-radius:6px;background:var(--ink-100);font-size:.78rem;font-weight:700}.role-P{background:#e0f2fe;color:#075985}.role-I{background:var(--teal-100);color:var(--teal-800)}.role-O{background:var(--orange-50);color:var(--orange-800)}.role-D{background:#ede9fe;color:#5b21b6}.strategy-tabs{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:10px;margin-bottom:12px}.strategy-tab{display:flex;flex-direction:column;align-items:flex-start;gap:2px;padding:12px 14px;border:1px solid var(--ink-200);border-radius:12px;background:var(--ink-50);color:var(--ink-700);font:inherit;text-align:left;cursor:pointer}.strategy-tab.active{border-color:var(--teal-600);background:var(--teal-50);box-shadow:inset 0 -3px 0 var(--orange-500)}.strategy-name{font-weight:800;color:var(--ink-900)}.strategy-meta{font-size:.82rem;color:var(--ink-500)}.strategy-intent{margin:0 0 12px;font-size:.9rem;color:var(--ink-600)}.query-card{border:1px solid var(--ink-200);border-radius:14px;overflow:hidden}.query-header{display:flex;flex-wrap:wrap;align-items:center;justify-content:space-between;gap:10px;padding:14px 18px;border-bottom:1px solid var(--ink-200);background:var(--ink-50)}.query-title{font-weight:800;color:var(--ink-900)}.query-stats{display:flex;flex-wrap:wrap;gap:8px}.stat{padding:4px 10px;border:1px solid var(--ink-200);border-radius:8px;background:#fff;font-size:.82rem}.stat-label{color:var(--ink-500)}.stat-value{font-weight:700;color:var(--ink-900)}.stat-value.success,.status-success{color:var(--success-700)}.stat-value.error,.status-error{color:var(--danger-700)}.status-warning{color:var(--amber-800)}.status-success,.status-warning,.status-error{font-weight:700}.query-body{padding:18px}.query-description{margin-bottom:12px;font-size:.9rem;color:var(--ink-600)}.query-issues{margin-bottom:12px;padding:10px 14px;border-radius:10px;font-size:.88rem}.query-issues p{margin:2px 0}.query-issues.error{background:var(--danger-50);color:var(--danger-700)}.query-issues.warning{background:var(--amber-50);color:var(--amber-800)}.database-tabs{display:flex;flex-wrap:wrap;gap:6px;margin-bottom:10px}.db-tab{display:inline-flex;align-items:center;gap:6px;min-height:36px;padding:6px 12px;border:1px solid var(--ink-300);border-radius:8px;background:#fff;color:var(--ink-700);font:inherit;font-size:.86rem;font-weight:600;cursor:pointer}.db-tab.active{border-color:var(--teal-700);background:var(--teal-700);color:#fff}.validate-badge{font-size:.75rem}.warn-badge{display:inline-grid;place-items:center;width:18px;height:18px;border-radius:50%;background:var(--orange-500);color:#fff;font-size:.7rem;font-weight:800}.query-string{position:relative;padding:16px 84px 16px 16px;border-radius:10px;background:var(--ink-900);color:#e2e8f0}.query-string code{display:block;font-family:var(--font-code);font-size:.86rem;line-height:1.7;white-space:pre-wrap;word-break:break-word}.copy-btn{position:absolute;top:10px;right:10px;min-height:32px;padding:4px 12px;border:0;border-radius:8px;background:var(--teal-600);color:#fff;font:inherit;font-size:.8rem;font-weight:700;cursor:pointer}.query-unavailable{margin:0;color:#fecaca}.search-link{display:inline-block;margin-top:12px;font-size:.9rem;font-weight:700}.query-translation,.metrics-help{margin-top:12px;font-size:.88rem}.query-translation summary,.metrics-help summary{cursor:pointer;font-weight:700;color:var(--teal-800)}.query-translation code{display:block;margin-top:8px;padding:10px 12px;border-radius:8px;background:var(--ink-100);font-family:var(--font-code);font-size:.82rem;white-space:pre-wrap;word-break:break-word}.metrics-help{margin-top:20px;padding:14px 18px;border:1px solid var(--ink-200);border-radius:12px;background:var(--ink-50)}.metrics-help dl{margin:12px 0 0}.metrics-help dt{font-weight:700;color:var(--ink-900)}.metrics-help dd{margin:2px 0 10px;color:var(--ink-600)}.database-note{margin-top:12px;padding:12px 14px;border-left:3px solid var(--orange-500);border-radius:0 10px 10px 0;background:var(--orange-50);font-size:.88rem}.database-note p{margin:0}.note-warning{color:var(--amber-800)}.translation-warnings{margin:8px 0 0;padding-left:1.2em}.missing-pmids{margin-top:12px;padding:10px 14px;border-radius:10px;background:var(--danger-50);color:var(--danger-700);font-size:.88rem}.section-intro{display:grid;grid-template-columns:150px minmax(0,1fr);align-items:center;gap:20px;margin-bottom:16px}.section-intro img{mix-blend-mode:multiply}.section-intro h2{margin-bottom:6px}.section-intro p{margin:0}.blog-input-row{display:grid;grid-template-columns:minmax(0,1fr) auto;align-items:end;gap:16px}.blog-topic-input label,.blog-query-select label{display:block;margin-bottom:6px;font-size:.86rem;font-weight:600}.blog-loading{margin-top:16px;text-align:center;color:var(--ink-600)}.blog-result{margin-top:20px}.blog-header{display:flex;flex-wrap:wrap;align-items:center;justify-content:space-between;gap:12px;margin-bottom:12px}.blog-header h3{margin:0}.blog-meta{display:flex;flex-wrap:wrap;gap:6px 14px;font-size:.85rem;color:var(--ink-500)}.blog-quality-warnings{margin:12px 0;padding:14px 18px;border:1px solid #fde68a;border-radius:12px;background:var(--amber-50);color:var(--amber-800)}.blog-quality-warnings h4{margin-bottom:6px}.blog-quality-warnings ul{margin:0;padding-left:1.2em}.blog-content{padding:24px 28px;border:1px solid var(--ink-200);border-radius:12px;background:#fff}.blog-article{max-width:72ch;line-height:1.85}.blog-article h1,.blog-article h2,.blog-article h3{color:var(--ink-900)}.blog-article blockquote{margin:16px 0;padding:10px 14px;border-left:3px solid var(--orange-500);background:var(--orange-50)}.blog-references{margin-top:16px;font-size:.88rem}.blog-references ul{padding-left:1.2em}.ref-category{margin:12px 0 6px}.ref-uncited{margin-left:6px;color:var(--amber-800)}.site-footer{background:var(--ink-900);color:#cbd5e1;font-size:.88rem}.footer-top{padding:40px 0 28px}.footer-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:32px}.footer-heading{margin-bottom:14px;font-size:.85rem;font-weight:700;color:#f1f5f9}.footer-column ul{margin:0;padding:0;list-style:none}.footer-column li{margin-bottom:12px}.site-footer a{color:var(--teal-200);text-underline-offset:3px}.site-footer a:hover{color:#fff}.footer-follow-list{display:flex;flex-wrap:wrap;gap:12px}.footer-follow-list li{margin:0}.footer-follow-list a{display:grid;place-items:center;width:46px;height:46px;border:1px solid rgba(255,255,255,.12);border-radius:50%;background:#ffffff0a;color:#e2e8f0}.footer-follow-list a:hover{border-color:var(--teal-200);background:var(--teal-800)}.footer-about,.footer-bottom{color:#94a3b8}.footer-about{margin-top:24px}.footer-about p,.footer-bottom p{margin:0 0 6px}.footer-bottom{padding:20px 0 28px;border-top:1px solid rgba(255,255,255,.1)}.footer-bottom-inner{display:flex;justify-content:space-between;gap:24px}.footer-bottom-inner p:last-child{max-width:60ch;text-align:right}.error-boundary{max-width:560px;margin:80px auto;padding:32px;border-radius:var(--radius-card);background:#fff;text-align:center;box-shadow:var(--shadow-card)}@media(max-width:900px){.hero{grid-template-columns:minmax(0,1fr);padding:28px}.hero-art{order:-1;max-width:480px;margin:0 auto}.input-grid,.step-grid{grid-template-columns:minmax(0,1fr)}.step-card{display:grid;grid-template-columns:120px minmax(0,1fr);column-gap:16px}.step-card img{grid-row:1 / span 2;width:120px;height:100px;margin:0}.footer-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.footer-grid .footer-column:last-child{grid-column:1 / -1}}@media(max-width:640px){.shell{padding:0 16px}.main{padding-top:20px}.app-header-inner{min-height:60px}.maker{display:none}.brand-title{font-size:1.02rem}.hero{padding:22px 20px;border-radius:18px}.input-section,.articles-section,.terms-section,.queries-section,.blog-section,.loading-section,.warnings-section,.how-it-works{padding:20px}.button-row .btn{flex:1 1 100%}.step-card{grid-template-columns:minmax(0,1fr)}.step-card img{grid-row:auto;margin:0 auto 10px}.strategy-tabs{grid-template-columns:minmax(0,1fr)}.result-nav{flex-wrap:nowrap;overflow-x:auto}.result-nav a{flex:none}.section-intro,.blog-input-row{grid-template-columns:minmax(0,1fr)}.section-intro img{width:140px}.blog-content{padding:18px}.footer-grid{grid-template-columns:minmax(0,1fr)}.footer-bottom-inner{flex-direction:column;gap:4px}.footer-bottom-inner p:last-child{text-align:left}}@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*,*:before,*:after{animation-duration:.01ms!important;transition-duration:.01ms!important}}@media print{.app-header,.site-footer,.result-nav,.input-section,.button-row,.export-buttons,.copy-btn{display:none!important}}